McDonald's in Orangeburg, South Carolina

Updated 2026

There are 3 McDonald's locations in Orangeburg, South Carolina.

About McDonald's in Orangeburg

A go-to destination for Orangeburg shoppers, each of the three McDonald's locations in town offers familiar favorites like burgers, fries, and shakes at quick-service counters, making them a reliable spot for both locals and visitors seeking a taste of home or a quick bite on the go.

McDonald's - Orangeburg

2394 Chestnut Ne, Orangeburg, SC 29115

803-536-5090

Monday-Thursday: 5:00am-11:00pm, Friday-Saturday: 5:00am-12:00am, Sunday: 5:00am-11:00pm

McDonald's - Orangeburg

3675 Saint Matthews Rd, Orangeburg, SC 29118

803-536-1234

Monday-Thursday: 5:00am-12:00am, Friday-Saturday: 5:00am-1:00am, Sunday: 5:00am-12:00am

McDonald's - Orangeburg

706 John C Calhoun Dr, Orangeburg, SC 29115

803-536-1111

Monday-Sunday: 5:30am-12:00am

McDonald's locations & hours near Orangeburg

14 miles

McDonald's - Bowman

2064 Homestead Rd, Bowman, SC 29018

803-829-4414

17 miles

McDonald's - Bamberg

3668 E Railroad Ave, Bamberg, SC 29003

19 miles

McDonald's - Denmark

18128 Heritage Hwy, Denmark, SC 29042

803-793-0206

23 miles

McDonald's - Santee

8409 Old Number Six Hwy, Santee, SC 29142

803-854-2634

27 miles

McDonald's - St. George

6005 W Jim Bilton Blvd, St. George, SC 29477

843-563-9218

29 miles

McDonald's - Hopkins

117 Bunch Lane, Hopkins, SC 29061

803-887-2233

30 miles

McDonald's - Cayce

2929 Charleston Hwy, Cayce, SC 29033

803-796-1995

30 miles

McDonald's - Columbia

2015 Bluff Road, Columbia, SC 29201

803-252-4727

30 miles

McDonald's - Summerton

401 Buff Blvd, Summerton, SC 29148

803-488-0188

30 miles

McDonald's - Columbia

7501 Garners Ferry Rd, Columbia, SC 29209

803-776-6685

32 miles

McDonald's - West Columbia

2700 Emanuel Church Rd, West Columbia, SC 29169

803-957-7772

32 miles

McDonald's - Columbia

4801 Garners Ferry Rd, Columbia, SC 29209

803-787-0934

Other Stores in Orangeburg

Dollar General 10 Family Dollar 3 Wendy's 3 Dollar Tree 3 Starbucks 2 Advance Auto Parts 2 Walgreens 2 T.J.Maxx 1 Walmart 1 GameStop 1 Public Storage 1 AT&T 1 Petco 1 Lowes 1 GNC 1 Rent-A-Center 1 Verizon Wireless 1 AutoZone 1 CVS 1 ALDI 1

McDonald's in Orangeburg

There are 3 McDonald's locations in Orangeburg, South Carolina. Each listing includes the store address, phone number, and opening hours. Select a McDonald's store in Orangeburg for full details, a map, and directions.