McDonald's in Florence, South Carolina

Updated 2026

There are 7 McDonald's locations in Florence, South Carolina.

About McDonald's in Florence

A go-to destination for Florence shoppers, McDonald's provides a variety of quick-service meals and beverages that cater to the bustling lifestyle of the city. With eight convenient locations throughout Florence, residents can easily grab their favorite menu items whether they're on the go or looking for a comfortable spot to enjoy a meal with friends and family.

McDonald's - Florence

1389 Celebration Blvd, Florence, SC 29501

843-667-9887

Monday-Sunday: 5:00am-12:00am

McDonald's - Florence

1540 S Irby St, Florence, SC 29505

843-662-6762

Open 24 Hours

McDonald's - Florence

1908 W Lucas St, Florence, SC 29501

843-669-4546

Monday-Thursday: 5:00am-11:00pm, Friday-Saturday: 5:00am-12:00am, Sunday: 5:00am-11:00pm

McDonald's - Florence

2016 W Palmetto, Florence, SC 29501

843-669-4012

Monday-Sunday: 5:00am-12:00am

McDonald's - Florence

2961 Williston Rd, Florence, SC 29506

843-679-3365

Monday-Sunday: 5:00am-12:00am

McDonald's - Florence

3805 W Palmetto St, Florence, SC 29501

843-679-0167

Monday-Wednesday: 5:00am-11:00pm, Thursday-Saturday: 5:00am-12:00am, Sunday: 5:00am-11:00pm

McDonald's - Florence

4735 E Palmetto Street, Florence, SC 29506

843-673-9601

Monday-Sunday: 5:00am-12:00am

McDonald's locations & hours near Florence

8 miles

McDonald's - Darlington

1501 S Main St, Darlington, SC 29532

843-393-9733

18 miles

McDonald's - Hartsville

431 Hartsville Crossing Rd, Hartsville, SC 29550

843-332-4752

20 miles

McDonald's - Lake City

203 N Ron Mcnair Blvd, Lake City, SC 29560

843-394-2283

20 miles

McDonald's - Latta

1364a Highway 38 W, Latta, SC 29565

843-752-2060

25 miles

McDonald's - Bishopville

1101 Sumter Hwy, Bishopville, SC 29010

803-428-6059

26 miles

McDonald's - Marion

2513 E Highway, Marion, SC 29571

843-423-0104

31 miles

McDonald's - Dillon

310 Hwy 301 N, Dillon, SC 29536

843-774-7585

31 miles

McDonald's - Bennettsville

108 Hwy 15-401 Bypass W, Bennettsville, SC 29512

843-479-8399

Other Stores in Florence

Dollar General 11 CVS 6 Starbucks 5 Wendy's 5 Dunkin' Donuts 4 Advance Auto Parts 4 Dollar Tree 4 Walmart 3 Family Dollar 3 Pizza Hut 3 Verizon Wireless 2 Public Storage 2 GameStop 2 AT&T 2 AutoZone 2 Walgreens 2 ALDI 2 Kohl's 1 Home Depot 1 Ross 1

McDonald's in Florence

There are 7 McDonald's locations in Florence, South Carolina. Each listing includes the store address, phone number, and opening hours. Select a McDonald's store in Florence for full details, a map, and directions.