McDonald's in Depew, New York

Updated 2026

There are 3 McDonald's locations in Depew, New York.

About McDonald's in Depew

Whether you live in downtown Depew or nearby, McDonald's provides a familiar spot for quick bites and meals, catering to the busy lives of Depew residents with classic menu items that bring communities together. With two convenient locations within the city, locals can easily grab their favorite burgers, fries, and shakes without leaving Depew.

McDonald's - Depew

4993 Transit Road State Rte 78, Depew, NY 14043

716-681-4725

Monday-Sunday: 6:00am-11:00pm

McDonald's - Depew

5150 Broadway Avenue, Depew, NY 14086

716-226-3057

Monday-Saturday: 5:30am-12:00am, Sunday: 6:00am-12:00am

McDonald's - Depew

6360 Transit St, Depew, NY 14043

716-226-3053

Monday-Sunday: 5:45am-12:00am

McDonald's locations & hours near Depew

2 miles

McDonald's - Cheektowaga

2567 Union Rd, Cheektowaga, NY 14227

716-656-7846

3 miles

McDonald's - Cheektowaga

4217 Genesee St, Cheektowaga, NY 14225

716-226-3056

3 miles

McDonald's - Cheektowaga

3815 Union Rd, Cheektowaga, NY 14225

716-683-3376

4 miles

McDonald's - Cheektowaga

1735 Walden Ave, Cheektowaga, NY 14225

716-895-5265

4 miles

McDonald's - West Seneca

1154 Union Rd, West Seneca, NY 14224

716-674-7170

4 miles

McDonald's - Cheektowaga

2256 Clinton St, Cheektowaga, NY 14206

716-332-2198

6 miles

McDonald's - Williamsville

5316 Main St, Williamsville, NY 14221

716-204-0336

6 miles

McDonald's - Buffalo

1970 Kensington Ave, Buffalo, NY 14215

716-839-2957

6 miles

McDonald's - Lackawanna

1234 Abbott Rd, Lackawanna, NY 14218

716-226-3051

6 miles

McDonald's - Orchard Park

3232 Orchard Park Rd, Orchard Park, NY 14127

716-675-0352

6 miles

McDonald's - Buffalo

1028 Mc Kinley Pky, Buffalo, NY 14220

716-821-1211

6 miles

McDonald's - Williamsville

4987 Transit Rd, Williamsville, NY 14221

716-204-0089

Other Stores in Depew

Starbucks 3 Advance Auto Parts 3 Dollar Tree 3 GameStop 2 Dollar General 2 Verizon Wireless 2 Pizza Hut 2 Wendy's 2 ALDI 2 T.J.Maxx 1 AT&T 1 Walmart 1 Petco 1 Kohl's 1 7-Eleven 1 Walgreens 1 AutoZone 1 Ace Hardware 1 GNC 1 Target 1

McDonald's in Depew

There are 3 McDonald's locations in Depew, New York. Each listing includes the store address, phone number, and opening hours. Select a McDonald's store in Depew for full details, a map, and directions.