McDonald's in Desoto

McDonald's at 12955 State Rt 21, Desoto, Missouri. Find store hours, phone number, driving directions and answers to frequently asked questions below.

Located at 12955 State Rt 21, this McDonald's is a cornerstone of Desoto’s local community, offering quick and affordable dining options for residents on-the-go. Whether you're stopping by for a classic Big Mac or enjoying a refreshing McCafe beverage, the restaurant caters to busy schedules with its efficient drive-thru service.

Address & Contact

McDonald's

12955 State Rt 21,
Desoto, MO 63020

636-337-7845

Store information verified in 2026

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Store Hours

Monday5:00am - 11:00pm

Tuesday5:00am - 11:00pm

Wednesday5:00am - 11:00pm

Thursday5:00am - 11:00pm

Friday5:00am - 12:00am

Saturday5:00am - 12:00am

Sunday5:00am - 11:00pm

Store hours may vary. Please call to confirm.

Drive-Thru Hours

Monday5:00am - 12:00am

Tuesday5:00am - 12:00am

Wednesday5:00am - 12:00am

Thursday5:00am - 12:00am

Friday5:00am - 1:00am

Saturday5:00am - 1:00am

Sunday5:00am - 12:00am

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Location & Map

McDonald's - Desoto is located on 12955 State Rt 21, Desoto, MO 63020

Drive-Thru Free Wi-Fi Indoor Dining Delivery Mobile Order & Pay Gift Cards

Delivery available via Uber Eats.

Nearby Locations

McDonald's - Hillsboro
10229 State Rte 21, Hillsboro, MO 63050

7 miles

McDonald's - Festus
1150 Gannon Dr, Festus, MO 63028

10 miles

McDonald's - Festus
515 S Truman, Festus, MO 63028

11 miles

McDonald's - Pevely
1701 Highway Z, Pevely, MO 63070

13 miles

McDonald's - Barnhart
111 Catlin Xing, Barnhart, MO 63012

17 miles

McDonald's - Potosi
800 E High St, Potosi, MO 63664

18 miles

Frequently Asked Questions

Is this the only McDonald's in Desoto?

Yes, this is the only McDonald's located in Desoto.

How can I get directions or call this McDonald's?

You can call 636-337-7845 for any inquiries about hours and directions to the restaurant.

What are the drive-thru hours for McDonald's at 12955 State Rt 21, Desoto?

Drive-thru hours: Monday 5:00am - 12:00am, Tuesday 5:00am - 12:00am, Wednesday 5:00am - 12:00am, Thursday 5:00am - 12:00am, Friday 5:00am - 1:00am, Saturday 5:00am - 1:00am, Sunday 5:00am - 12:00am.

Does McDonald's at 12955 State Rt 21, Desoto offer delivery?

Yes, this McDonald's is available for delivery through Uber Eats.

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