CVS CVS in Southbridge

CVS at 399 MAIN STREET, Southbridge, Massachusetts. Find store hours, phone number, driving directions and answers to frequently asked questions below.

This CVS store in Southbridge at 399 Main Street is a one-stop destination for all your health and wellness needs, offering a wide range of pharmaceuticals, personal care products, and convenience items. The pharmacy provides convenient prescription services and MinuteClinic consultations right on-site. Shoppers can also find Morin Jewelers nearby to explore after picking up their medications.

Address & Contact

CVS

399 MAIN STREET,
Southbridge, MA 01550
508-765-0646
Store information verified in 2026
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Store Hours

Monday7:00am - 10:00pm
Tuesday7:00am - 10:00pm
Wednesday7:00am - 10:00pm
Thursday7:00am - 10:00pm
Friday7:00am - 10:00pm
Saturday7:00am - 10:00pm
Sunday7:00am - 10:00pm

Store hours may vary. Please call to confirm.

Pharmacy Hours

Monday9:00am - 9:00pm
Tuesday9:00am - 9:00pm
Wednesday9:00am - 9:00pm
Thursday9:00am - 9:00pm
Friday9:00am - 9:00pm
Saturday9:00am - 6:00pm
Sunday10:00am - 6:00pm

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Location & Map

CVS - Southbridge is located on 399 MAIN STREET, Southbridge, MA 01550

Pharmacy Photo Center Retail ATM Drive-Thru Pharmacy SNAP/EBT Accepted Drug Disposal Same-Day Delivery Buy Online, Pick Up In Store Immunizations UPS Access Point

Nearby Locations

CVS Pharmacy #10649 - Sturbridge
362 MAIN ST, Sturbridge, MA 01566
3 miles
CVS - Charlton
142 WORCESTER RD, Charlton, MA 01507
5 miles
CVS - Webster
112 E. MAIN ST, Webster, MA 01570
8 miles
CVS - Oxford
302 MAIN STREET, Oxford, MA 01540
9 miles
CVS - Spencer
95 MAIN STREET, Spencer, MA 01562
11 miles
CVS - Auburn
676 SOUTHBRIDGE STREET, Auburn, MA 01501
11 miles

Frequently Asked Questions

What are the regular operating hours for this CVS location?

This CVS is open Monday through Sunday from 7am to 10pm.

How can I find the CVS on Main Street? Is there a recognizable landmark near it?

The CVS store at 399 Main Street in Southbridge is conveniently located close to Morin Jewelers, which is just a short walk away and serves as an easy-to-spot landmark.

How can I get more information or directions for the CVS on Main Street?

For more information or to call directly, you can reach this CVS store at 508-765-0646.

What are the pharmacy hours for CVS at 399 MAIN STREET, Southbridge?

Pharmacy hours: Monday 9:00am - 9:00pm, Tuesday 9:00am - 9:00pm, Wednesday 9:00am - 9:00pm, Thursday 9:00am - 9:00pm, Friday 9:00am - 9:00pm, Saturday 9:00am - 6:00pm, Sunday 10:00am - 6:00pm.

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